Triglycerides - Triglycerides Independent Risk Factor for CAD

Triglycerides Independent Risk Factor for CAD

According to many epidemiological studies, elevated plasma triglyceride levels fasting or non- fasting form an independent risk factor for cardiovascular diseases.

Framingham Heart Study, after 30 years' follow up, shows a correlation of increased cardiovascular risk with elevated triglyceride levels. This association was stronger in women.

Moreover, Hokanson and Austin have published the results of a meta-analysis of 17 clinical trials with a total number of 46.413 men and 10864 women, showing a similar correlation between elevated plasma triglyceride level and risk for vascular diseases. This correlation remained even after correction for Low Density Lipoprotein cholesterol.

The Copenhagen City Heart Study, which observed 14,000 Danish (men and women) for 26 years, shows that non-fasting triglyceride levels correlate with an increased risk for cardiovascular events in both sexes. It was also shown that, when the non-fasting triglyceride levels are ≥ 440 mg / dl there is a 17 fold increase in women and 5 fold increase in men for myocardial infarction.

Finally, Asia Pacific Cohort Studies Collaboration study shows that there is a stronger correlation between non-fasting triglyceride levels and the prediction of CVD events.

The above studies led
• The European Atherosclerosis Society [1]
• The American Heart Association Scientific Statement [2] and
• The Expert Panel Statement [3]

to conclude that according to the current data there are many elements confirming that high plasma triglyceride levels (fasting and postprandial), increase the risk for cardiovascular diseases.

References:
1. ESC/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). European Association for Cardiovascular Prevention & Rehabilitation, Reiner Z, et al. Eur Heart J. 2011 July;32(14):1769-818.
2. Miller M, et al. Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association. Circulation. 2011 May 24;123(20):2292-333.
3. Kolovou GD, Mikhailidis DP, Kovar J, Lairon D, Nordestgaard BG, Ooi TC, Perez-Martinez P, Bilianou H, Anagnostopoulou K, Panotopoulos G. Assessment and clinical relevance of non-fasting and postprandial triglycerides: an expert panel statement. Curr Vasc Pharmacol. 2011 May;9(3):258-70