Diagnostic value of Fat Tolerance Test
The importance of measuring postprandial triglycerides:
The main metabolic disorder postprandially is the increased triglyceride levels. The degree of response after the meal (if the fat is metabolized rapidly or not) plays a crucial role in the development of atherosclerosis process.
The Framingham Heart Study, a meta-analysis of 17 clinical trials by Hokanson and Austin (it should be mentioned that 46,413 men and 10,864 women participated in it), the Copenhagen City Heart study and the Asia Pacific Cohort Studies Collaboration confirmed that: elevated plasma triglyceride levels increase the risk for cardiovascular diseases.
However until recently, there was a major diagnostic problem in the determination of postprandial hypertriglyceridemia.
It is well known that, the morning sample for determination of triglyceride levels cannot accurately predict the pathological postprandial triglyceride levels due to the long period of fasting. This fact makes the postprandial triglyceride level determination and evaluation imperative.
The importance of determination of the postprandial triglyceride (Fat Tolerance Test) is also supported by many clinical studies, including:
• The Women's Health Study
• The Copenhagen City Heart Study
• The Physicians Health Study
• The Apolipoprotein-related Mortality Risk Study
• The second Northwick Park Heart Study and
• The Norwegian Study
The diagnostic value of the Fat Tolerance Test is that it defines exactly the way of determination and evaluation of postprandial triglyceride levels.